Skip to Content

ABOUT WRAP:

 

FOR WRAP PARTICIPANTS:

 

FOR RESEARCHERS:

 

SITE CONTACTS:

  • MADISON: Shawn Bolin
    sbolin@wisc.edu
    Phone: 608-263-2854
    Toll-free: 1-800-417-4169

  • LA CROSSE: Carolyn Flock
    flock.carolyn@mayo.edu
    Phone: 608-392-7187
    Toll-free: 1-800-362-5454, ext. 27187

  • MILWAUKEE: Nia Norris
    ncnorris@wisc.edu
    Phone: 414-219-5159

WRAP Publications

WRAP research staff continuously publish articles and scientific papers on their research efforts related to Alzheimer's disease. Below are publications from 2016-2017, starting with 2017 at the top. We've provided a link to each publication.

 

2017

Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults

Sprecher KE, Koscik RL, Carlsson CM, Zetterberg H, Blennow K, Okonkwo OC, Sager MA, Asthana S, Johnson SC, Benca RM, Bendlin BB
Neurology. 2017 Jul 5. pii: 10.1212/WNL.0000000000004171. [Epub ahead of print]

 

Moderate Physical Activity is Associated with Cerebral Glucose Metabolism in Adults at Risk for Alzheimer’s Disease

Dougherty RJ, Schultz SA, Kirby TK, Boots EA, Oh JM, Edwards DF, Gallagher CL, Carlsson CM, Bendlin BB, Asthana S, Sager MA, Hermann BP, Christian BT, Johnson SC, Cook DB, Okonkwo OC.
Journal of Alzheimer's Disease. 2017;58(4):1089-1097.

 

Association of longitudinal white matter degeneration and cerebrospinal fluid biomarkers of neurodegeneration, inflammation and Alzheimer's disease in late-middle-aged adults

Racine AM, Merluzzi AP, Adluru N, Norton D, Koscik RL, Clark LR, Berman SE, Nicholas CR, Asthana S, Alexander AL, Blennow K, Zetterberg H, Kim WH, Singh V, Carlsson CM, Bendlin BB, Johnson SC.
Brain Imaging Behav. 2017 Jun 9. doi: 10.1007/s11682-017-9732-9. [Epub ahead of print]

 

BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention

Boots EA, Schultz SA, Clark LR, Racine AM, Darst BF, Koscik RL, Carlsson CM, Gallagher CL, Hogan KJ, Bendlin BB, Asthana S, Sager MA, Hermann BP, Christian BT, Dubal DB, Engelman CD, Johnson SC, Okonkwo OC.
Neurology. 2017 May 30;88(22):2098-2106. doi: 10.1212/WNL.0000000000003980. Epub 2017 May 3.

 

Family history and TOMM40 '523 interactive associations with memory in middle-aged and Alzheimer's disease cohorts

Willette AA, Webb JL, Lutz MW, Bendlin BB, Wennberg AM, Oh JM, Roses A, Koscik RL, Hermann BP, Dowling NM, Asthana S, Johnson SC; Alzheimer's Disease Neuroimaging Initiative
Alzhimer's & Dementia. 2017 May 10. pii: S1552-5260(17)30148-6. doi: 10.1016/j.jalz.2017.03.009. [Epub ahead of print]

 

Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD

Schultz SA, Boots EA, Darst BF, Zetterberg H, Blennow K, Edwards DF, Koscik RL, Carlsson CM, Gallagher CL, Bendlin BB, Asthana S, Sager MA, Hogan KJ, Hermann BP, Cook DB, Johnson SC, Engelman CD, Okonkwo OC
Neurology. 2017 Apr 25;88(17):1650-1658. Epub 2017 Mar 24.

 

Positive affect predicts cerebral glucose metabolism in late middle-aged adults

Nicholas C, Hoscheidt SM, Clark LR, Racine AM, Berman SE, Koscik RL, Maritza Dowling N, Asthana S, Christian BT, Sager MA, Johnson SC.
Social Cognitive and Affective Neuroscience. 2017 Apr 11. [Epub ahead of print]

 

Microstructural white matter alterations in preclinical Alzheimer's diseasedetected using free water elimination diffusion tensor imaging

Hoy AR, Ly M, Carlsson CM, Okonkwo OC, Zetterberg H, Blennow K, Sager MA, Asthana S, Johnson SC, Alexander AL, Bendlin BB.
PLoS One. 2017 Mar 14;12(3):e0173982. eCollection 2017.

 

Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer's disease

Dougherty RJ, Schultz SA, Boots EA, Ellingson LD, Meyer JD, Van Riper S, Stegner AJ, Edwards DF, Oh JM, Einerson J, Korcarz CE, Koscik RL, Dowling MN, Gallagher CL, Carlsson CM, Rowley HA, Bendlin BB, Asthana S, Hermann BP, Sager MA, Stein JH, Johnson SC, Okonkwo OC, Cook DB
Brain and Behavior. 2017 Feb 17;7(3):e00625. eCollection 2017.

 

Pathway-specific polygenic risk scores as predictors of β-amyloid deposition and cognitive function in a sample at increased risk for Alzheimer’s disease

Darst, B. F., Koscik, R. L., Racine, A. M., Oh, J. M., Krause, R. A., Carlsson, C. M., Zetterberg, H., Blennow, K., Christian, B. T., Bendlin, B. B., Okonkwo, O. C., Hogan, K. J., Hermann, B. P., Sager, M. A., Asthana, S., Johnson, S. C., & Engelman, C. D.
Journal of Alzheimer’s Disease. 2017;55(2):473-484.

 

Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease

Dean DC 3rd, Hurley SA, Kecskemeti SR, O'Grady JP, Canda C, Davenport-Sis NJ, Carlsson CM, Zetterberg H, Blennow K, Asthana S, Sager MA, Johnson SC, Alexander AL, Bendlin BB.
JAMA Neurol. 2017 Jan 1;74(1):41-49.

 

Chronotropic Response and Cognitive Function in a Cohort at Risk for Alzheimer's Disease

Law LL, Schultz SA, Boots EA, Einerson JA, Dougherty RJ, Oh JM, Korcarz CE, Edwards DF, Koscik RL, Dowling NM, Gallagher CL, Bendlin BB, Carlsson CM, Asthana S, Hermann BP, Sager MA, Johnson SC, Cook DB, Stein JH, Okonkwo OC.
J Alzheimers Dis. 2017;56(1):351-359.

 

2016

Mild Cognitive Impairment in Late Middle Age in the Wisconsin Registry for Alzheimer's Prevention Study: Prevalence and Characteristics Using Robust and Standard Neuropsychological Normative Data

Clark LR, Koscik RL, Nicholas CR, Okonkwo OC, Engelman CD, Bratzke LC, Hogan KJ, Mueller KD, Bendlin BB, Carlsson CM, Asthana S, Sager MA, Hermann BP, Johnson SC
Archives of Clinical Neuropsychology. 2016; 31(7):675–688.

 

Intraindividual Cognitive Variability in Middle Age Predicts Cognitive Impairment 8-10 Years Later: Results from the Wisconsin Registry for Alzheimer's Prevention

Koscik RL, Berman SE, Clark LR, Mueller KD, Okonkwo OC, Gleason CE, Hermann BP, Sager MA, Johnson SC.
J Int Neuropsychol Soc. 2016 Nov;22(10):1016-1025.

 

Associations between performance on an abbreviated CogState battery, other measures of cognitive function, and biomarkers in people at risk for Alzheimer’s disease

Racine AM, Clark LR, Berman SE, Koscik RL, Mueller KD, Norton D, Nicholas CR, Blennow K, Zetterberg H, Jedynak B, Bilgel M, Carlsson CM, Christian BT, Asthana S, Johnson SC
Journal of Alzheimer’s Disease. 2016 Oct 18;54(4):1395-1408.

 

Connected Language in Late Middle-Aged Adults at Risk for Alzheimer's Disease

Mueller KD, Koscik RL, Turkstra LS, Riedeman SK, LaRue A, Clark LR, Hermann B, Sager MA, Johnson SC
J Alzheimers Dis. 2016 Oct 18;54(4):1539-1550.

 

Reliability of a Novel Social Activity Questionnaire

Zuelsdorff ML, Koscik RL, Okonkwo OC, Peppard PE, Hermann BP, Sager MA, Johnson SC, Engelman CD
Journal of Aging and Health. 2016 Oct 1:898264316674812. [Epub ahead of print]

 

Biomarker clusters are differentially associated with longitudinal cognitive decline in late midlife

Annie M. Racine, Rebecca L. Koscik, Sara E. Berman, Christopher R. Nicholas, Lindsay R. Clark, Ozioma C. Okonkwo, Howard A. Rowley, Sanjay Asthana, Barbara B. Bendlin, Kaj Blennow, Henrik Zetterberg, Carey E. Gleason, Cynthia M. Carlsson, Sterling C. Johnson
Brain. 2016 Aug;139(Pt 8):2261-74. Epub 2016 Jun 20.

 

Beta-amyloid and cognitive decline in late middle age: Findings from the WRAP study

Clark, L. R., Racine, A. M., Koscik, R., Okonkwo, O. C., Engelman, C. D., Carlsson, C. M., Asthana, S., Bendlin, B. B., Chappell, R. J., Nicholas, C. R., Rowley, H. A., Oh, J., Hermann, B., Sager, M. A., Christian, B., & Johnson, S. C.
Alzheimers Dement. 2016 Jul;12(7):805-14.

 

Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging

Merluzzi AP, Dean DC 3rd, Adluru N, Suryawanshi GS, Okonkwo OC, Oh JM, Hermann BP, Sager MA, Asthana S, Zhang H, Johnson SC, Alexander AL, Bendlin BB).
Neurobiol Aging. 2016 Jul;43:79-88.

 

Meeting physical activity recommendations may be protective against temporal lobe atrophy in older adults at risk for Alzheimer's disease

Dougherty RJ, Ellingson LD, Schultz SA, Boots EA, Meyer JD, Lindheimer JB, Van Riper S, Stegner AJ, Edwards D, Oh JM, Koscik RL, Dowling MN, Gallagher CL, Carlsson CM, Rowley HA, Bendlin BB, Asthana S, Hermann BP, Sager MA, Johnson SC, Okonkwo OC, Cook DB
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring (Amst). 2016 Apr 9;4:14-7.

 

Fornix microstructure and memory performance is associated with altered neural connectivity during episodic recognition

Ly M, Adluru N, Destiche DJ, Lu SY, Oh JM, Hoscheidt SM, Alexander AL, Okonkwo OC, Rowley HA, Sager MA, Johnson SC, Bendlin BB
Journal of the International Neuropsychological Society. 2016 Feb;22(2):191-204.

 

Cerebrospinal Fluid Markers of Alzheimer's Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer's Disease

Melah KE, Lu SY, Hoscheidt SM, Alexander AL, Adluru N, Destiche DJ, Carlsson CM, Zetterberg H, Blennow K, Okonkwo OC, Gleason CE, Dowling NM, Bratzke LC, Rowley HA, Sager MA, Asthana S, Johnson SC, Bendlin BB

 

Cerebrospinal fluid ratios with Aβ42 predict preclinical brain β-amyloid accumulation

Racine AM, Koscik RL, Nicholas CR, Clark LR, Okonkwo OC, Oh JM, Hillmer AT, Murali D, Barnhart TE, Betthauser TJ, Gallagher CL, Rowley HA, Dowling NM, Asthana S, Bendlin BB, Blennow K, Zetterberg H, Carlsson CM, Christian BT, Johnson SC
Alzheimers Dement (Amst). 2016;2:27-38.


red bar